Drugs: effectiveness

Rheumatoid arthritis (RA) treatment and management guidelines [7, 8] recommend starting treatment with conventional synthetic disease-modifying anti-rheumatic monotherapy (csDMARD) such as hydroxychloroquine, leflunomide, methotrexate or sulfasalazine. Today, methotrexate (MTX) is the most widely used disease-modifying antirheumatic drug (DMARD) and the first to be “chosen” [1,2] for its efficacy, safety and cost [3.6] in the therapeutic […]

Rheumatoid Arthritis: a bit of history

The first unequivocal publication in which it is possible to recognize the pathology we know today as Rheumatoid Arthritis (RA) is relatively recent and dates back to just over two centuries ago. It was Augustin Jacob Landrè-Beauvais who spoke of it in his doctoral thesis. A physician at the Salpêtrière Hospital in Paris, Augustin described […]

Heterogeneity of synovial tissue in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a complex autoimmune disease that is genetically and biologically heterogeneous. It is characterized by inflammatory arthritis with strong systemic electivity. The treatment of patients with rheumatoid arthritis has evolved considerably in recent years thanks to the development and widespread use of biological disease-modifying anti-rheumatic drug therapies (bDMARDs) and, subsequently, with the […]

Baker’s Cyst: What Are They? Who Suffers?

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, also referred to as systemic connectivity with elective joint localization, with an erosive, deforming character and with a chronic-progressive trend that affects approximately 1% of the world population. This condition is characterized by the infiltration of neutrophils into the soft tissues which leads to hypertrophy of […]

Effects of rheumatoid arthritis on sexual activity and relationships

Living with a disease such as rheumatoid arthritis (RA) is not at all easy, one finds oneself facing it in everyday life with fluctuating phases; days in which it seems to have “won” in the morning and days when the disease is in an acute phase, in which even the most banal “gesture” like tying […]

Why aren’t biologics used right away if they’re so effective?

Although the etiopathogenesis of rheumatoid arthritis is not yet well understood, in the 1990s it was shown that chronic inflammation is caused by a disruption of the physiological balance between pro-inflammatory (in favor of inflammation) and anti-inflammatory proteins. (which inhibit inflammation). These pro-inflammatory proteins are termed CYTOKINES. Cytokines are produced by cells of the immune […]

Physical activity and Rheumatoid Arthritis: THE IMPORTANCE OF CORRECT MOVEMENT

It is widely recognized that regular exercise and physical activity provide multiple health benefits to the general population and to patients with chronic diseases. There are those who practice it for pleasure and those for work, those who appreciate its creative side and those who, while not practicing it, recognize its emotional power and the […]